Sertraline jaw clenching is one side effect of the drug. It isn’t neccesarily common, but it does happen. Luckily, there are alternatives, if you need them. Jaw clenching on zoloft (another name for Sertraline) may go away on its own, over time. However, if you’re feeling distress, it’s probably time to speak with your doctor.
Sertraline (also known as Zoloft) is used to treat depression, anxiety, OCD, PTSD, and premenstrual dysphoric disorder. The prescription medicine belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs), these work by increasing the levels of the neurotransmitter serotonin in the brain.

Sertraline/ Zoloft Common Side Effects
Like all medications, Sertraline/ Zoloft can cause side effects, although not everyone will experience them. Common side effects include:
- Nausea
- Diarrhoea
- Insomnia or drowsiness
- Headache
- Dizziness or lightheadedness
- Dry mouth
- Sweating
- Changes in appetite or weight
- Sexual problems, such as decreased sex drive, difficulty achieving orgasm, or erectile dysfunction
- Tremors or shaking
- Restlessness or agitation
- Blurred vision
- Muscle weakness or fatigue
- Increased sweating
Jaw clenching, also known as Bruxism, is a less common but still possible side effect of Sertraline/ Zoloft. Bruxism is when a person grinds their teeth against each other or clenches their jaw involuntarily.
The side effects of this drug are usually mild and go away on their own, but some people may experience more severe or persistent effects.
Rare Cases
In rare cases, Sertraline/ Zoloft can cause a condition called serotonin syndrome, which occurs when there is an excess of serotonin in the body. Symptoms can include
- Agitation
- Confusion
- Rapid heart rate
- High blood pressure
- Dilated pupils
- Muscle rigidity
In very rare, but very serious cases, Zoloft side effects may include suicidal thoughts or behaviour.
It’s also worth noting that while these drugs are generally well-tolerated, it may not be suitable for everyone. People with a history of bipolar disorder, seizures, or liver or kidney disease should use caution when taking Sertraline or Zoloft. Make sure to get medical attention if you experience any of the noted symptoms

Understanding the Mechanism of Sertraline Jaw Clenching
Sertraline jaw clenching is not understood fully, but it is thought it relates to the drug’s effect on serotonin levels in the brain. Zoloft works by blocking the reuptake of serotonin, which increases the levels of this neurotransmitter in the brain. Serotonin plays a role in regulating mood, sleep, and muscle tone.
Some think Sertraline jaw clenching may come from the drug’s effect on muscle tone. Serotonin regulates muscle tone. When there is an increase in serotonin levels, it can cause an increase in muscle tension, including in the muscles of the jaw. This can result in jaw clenching or teeth grinding, especially during sleep.
It’s important to note that not everyone who takes this drug will experience jaw clenching or teeth grinding. The severity of this side effect can also vary.
Alternative Medications Without the Side Effect of Sertraline Jaw Clenching
Sertraline/ Zoloft is one of many medications available for depression and anxiety in the world. So I’ve taken the time out of my day to list some alternatives for you that may not have the side effect of jaw clenching. These include:
Bupropion (Wellbutrin)
A medication that works by increasing the levels of dopamine and norepinephrine in the brain. It is often used to treat depression and may have a lower chance of jaw clenching as a side effect compared to SSRIs and SNRIs.
Selective Serotonin Reuptake Inhibitors (SSRIs)
Like Zoloft, these work by increasing the levels of serotonin in the brain. But, some SSRIs may have a lower chance of jaw clenching as a side effect compared to others. Examples include escitalopram (Lexapro) and fluoxetine (Prozac).
Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)
Work by increasing the levels of serotonin and norepinephrine in the brain. Examples include venlafaxine (Effexor) and duloxetine (Cymbalta).
Mirtazapine (Remeron)
A medication that works by increasing the levels of both serotonin and norepinephrine in the brain, but in a different way compared to SSRIs and SNRIs. It may have a lower incidence of jaw clenching compared to other antidepressants.

Does Bruxism from SSRI Go Away
Also related to the topic, you may be wondering, “does bruxism from SSRI go away?” SSRIs (selective serotonin reuptake inhibitors) have a low chance of causing bruxism (jaw clenching). However, a low chance doesn’t mean a zero percent chance, and SSRIs do negatively affect some people.
The short answer is that bruxism from SSRI may go away on its own. It should, but it doesn’t always. The best way to approach this situation is to consult with your doctor if you have any concerns.
Sertraline Jaw Clenching – Bruxism Treatment Birmingham
If you have been experiencing jaw clenching for a while or keep experiencing jaw clenching feel free to talk to us. Don’t suffer in silence, we’re here to help you.
Do you want a Bruxism treatment that:
- Lasts approximately 6 months?
- Only requires 24 hours of downtime?
- Is so painless that it requires no anaesthetic?
- Displays results by 4 weeks?
Then a Bruxism Botox treatment at Dr Aesthetica in Birmingham may be perfect for you! Botox for teeth grinding may seem like you’re using an aesthetic treatment to solve a physical ailment, but botox is amazing at delivering results when it comes to bruxism. It’s a safe, effective, and easy solution.
Book with us today, and get your sertraline jaw clenching issues handled ASAP.
This article was read and reviewed by the face of DR Aesthetica himself – DR Baldeep Farmah.

